Anticoagulant and Antipatelet (Coumarin)

Both A. Vogel of Munich and Nicholas Jean Baptise Gaston Guibourt of France independently isolated coumarin in tonka beans and sweet clover in 1820.  Warfarin is a derivative of coumarin.  It is sold under the brand name Coumadin.  This drug is frequently prescribed as a blood thinner used to treat blood clots and to prevent stroke in people with atrial fibrillation and valvular heart disease.  This drug is a part of the WHO List of Essential MedicinesCaution: A herb containing coumarin is usually considered an emmenagogue, and should not be used if one is pregnant or trying to conceive.   Alternatively, it is often used to regulate and harmonize menstrual flow.  In TCM, these herbs impact the heart meridian and are often listed as tonifying the blood.  The following are anticoagulant and antipatelet pharma drugs that herbs containing coumarin may interact with - not a comprehensive list.

Plant: Tonka Beans

Other plants containing coumarin:
• American ginseng Panax quinquefolius  西洋参
Arnica Arnica montana
Cassia cinnamon Cinnamomum cassia
Chamomile  Matricaria chamomilla
• Dan shen Salvia miltiorrhiza Bge  丹参
Dang gui Angelica Sinensis 当归
Deertongue Dichanthelium clandestinum
 Ginger  Zingiber officinale  生姜
 Goji Berry Lycium barbarum L. 
• Ginkgo nuts Ginkgo biloba L. 银杏, 白果
Korean ginseng Panax ginseng  人参
• Notoginseng Panax notoginseng  三七
• Peach kernel Prunus persica [L.] Batsch, Semen persicae  桃仁
• Safflower Carthamus tinctorius L. 红花
Sweet clover Melilotus sp
• Vanilla grass Anthoxanthum odoratum

Interaction between warfarin and Chinese herbal medicines

Drug: Coumadin

Drug: enoxaparin

Drug: Asprin




Laxatives, Diuretics

Laxatives can be food or medication used to induce bowel movements or to loosen the stools.  It's usually used for constipation.  Too much can cause diarrhea.  Laxatives fall into different categories. 1. Stool-softeners are used to penetrate the stools with fats and water to help move stool (Ex-Colace).  2. Lubricants are used to make the stool more slippery.  3. Bulk-producing agents where the drug makes stool bulkier and retain more water (metamucil, broccoli).   4. Hydrating agents are used to retain water inside the intestine to soften the stool. 5. Hyperosmotic agents are used to draw water into the bowels. 6. Stimulants are used to increase contractions to push the stool along.

Diuretics can be food or medication to increase the production of urine to expell water and salt from the body.  It's commonly used to treat high blood pressure and congestive heart failure by reducing fluid buildup.


Herbs with Laxative Effects:
• Hibiscus,
• Chamomile,
• Asparagus,
• Dragon Fruit,
• Zhu ling (Polypori Umbellati)
• Che qian zi (Semen plantaginis)
 Ze xie (Alismatis orientalis)
• Mu Tong (Akebia trifoliata)

Herbs with Diuretic Effects:

Heal All,

Pharmaceutical Laxatives:
• Castor Oil
• Citrucel
• Colace Surfak
• Correctol
• Dulcolax
• Ex-Lax
• Fleet Enema
• Fleet Phospho-Soda
• GlycoLax
• Magnesium Citrate
• Milk of Magnesia
• MiraLax
• Metamucil
• Microenema
• Senokot

Pharmaceutical Diuretics
• Acetazolamide
• Aldactone
• Amiloride hydrochloride
• Bumex
• Diuril
• Diulo
• Demadex
• Dyrenium
• Edecrin
• Enduron
• Hydrodiuril
• Hygroton
• Lasix
• Lozol
• Methazolamide
• Mykrox
• Zaroxolyn

Hypoglycemic, Diabetic

Your pancreas creates the insulin hormone to help your cells turn the glucose from what you eat into energy.   Takes two parts to make this work - the pancreas and cells.  Type 1 diabetes is where the pancreas doesn't produce insulin right. Type 2 Diabetes is where the cells don't use the insulin like it's suppose to - causing insulin resistance.   Most people have Type 2.  If you are at risk of getting diabetes, you are prediabetic.  If you have diabetes during pregnancy due to hormonal changes, it's call Gestational Diabetes.  

<5 types of Diabetes> <Editor Experience>

Herbs with Blood Sugar Lowering Effects:
• Roses, Mei Gui Hua
• Eucommia, Du Zhong
• Bell Flower, Dang Shen
• Dragon Fruit, HuǒLong Guo
• Cinnamon, ròuguì
• Celery
• Chamomile
• Moringa Tree
• Basil
• Bitter Melon, Ku Gua
• Artichoke
• Hibiscus
• Goji Berry, Gou Qi Zi
• Chrysanthemum, júhuā
• Heal All, Xia Ku Cao
• Angelica Sinensis, Dang Gui
• Zhi mu (Anemarrhena asphodeloidis)
• Shi gao (Gypsum fibrosum)
• Xuan shen (Scrophularia ningpoensis)
• Cang Zhu (Atractylodes)
• Shan yao (Dioscorea oppositae)
• Huang qi (Astragalus membranacei)

Pharmaceutical Drugs for Diabetes 

• Acarbose (Precose )
• Alogliptin and metformin HCl Tablets (Kazano)
• Alogliptin and pioglitazone Tablets (Oseni )
• Albiglutide (Tanzeum)
• Alogliptin  (Nesina)
• Bromocriptine mesylate (CyclosetParlodel)
• Canaglifozin (Invokana)
• Canagliflozin and metformin (Invokamet)
• chlorpropamide (Diabinese)
• Dapagliflozin (Farxiga)
• Dulaglutide (Trulicity)
• Empagliflozin (Jardiance)
• Glimepiride (Amaryl)
• Glyburide (DiaBeta, Glynase)
• glipizide (Glucotrol)



• Insulin
• Miglitol (Glyset)
• Linagliptin (Tradjenta)
• Saxagliptin (Onglyza)
• Sitagliptin (Januvia)
• Nateglinide (Starlix)
• Repaglinide (Prandin)
• Tolazamide (Tolinase)
• Tolbutamide (Orinase, Tol-Tab)
• Rosiglitazone (Avandia)
• Pioglitazone (Actos)
• Pramlintide (SymlinPen 120, SymlinPen 60)

Sympathomimetic , Cardiac and Nervous System

(epinephrine, dopamine, isoproterenol / digoxin and ephedrine)

used to treat cardiac arrest and low blood pressure, or even delay premature labor,

Ephedra (Ma huang) contains ephedrine, and pseudoephedrine that interferes with this class of drugs.


Digoxin, enalapril, metoprolol, nitroglycerin, propranolol, Theophylline, caffeine, papverine. cyclopentamine, DOBUTamine,DOPamine, epHEDrine, isoproterenol, metaproterenol, metaraminol, mephentermine, methoxamine, methoxyphenamine,naphazoline, norepinephrine, phenylephrine, propylhexedrine, protokylol, pseudoephedrine, terbutaline sulfate,tetrahydrozoline, tuaminoheptane, xylometazoline, and epINEPHrin


Digoxin was isolated in foxglove specie digitalis purpurea in 1930.  Digoxin is sold under the drug name Lanoxin.  The medication is used for mild-to-moderate heart failures and arrhythmia.  The drug increases heart contractions and controls response rate of atrial fibrillation, therefore it makes the heart beat stronger and with a more regular rhythm. This drug is a part of the WHO List of Essential Medicines.   Caution: These plants are poisonous if ingested.

Plant: Purple Foxglove

Other plants containing dioxin:
Common oleander Nerium oleander
Lily-of-the-valley Convallaria majalis
Ouabain Strophanthus gratus
Woolly foxglove Digitalis lanata
Yellow oleander Thevetia peruviana


Drug: Lanoxin