Sophora Root, Kǔ Shēn, 苦参, Radix Sophorae Flavescentis

 Disclaimer    For educational purposes only.  Do not use as medical advice

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Health Benefits
For: Urinary track infection •  Hypertension •  Insomnia •  Diarrhea •  Genital sores • Herpes • Bronchial asthma • Bronchitis • Bacterial dysentery • Dysuria •  Intestinal bleeding •  Viral hepatitis •  Leukopenia
Attributes: hypotensive • immunostimulant  • antibiotic  • hepatoprotective  • antiparasitic  • sedative •  antiasthmatic •  anticancer •  antiarrhythmic  
Products (online examples)

Root

Granules

Granules

Granules

Root

Granules

Root

Root

Research (sample)

Articles:

Constituents: Oxymatrine •  Furanocoumarins  • Cytosine  • Kushenols •  Sophoridine  • Kurarinol •  Sophocarpine • Sophordine

Photos (Click to enlarge)
Fun Facts
Other Names: Ku Shen Gen • Yellow Sophora Root
Plant Family: Fabaceae

Species
Sophora Japonica
Growth
Sophora flavescens is in the USDA Plant Database.  Drill down via USDA Interactive Map:

USA: Sophora flavescens is not found in the wild.  

USDA Zones: 5-9

Native: East Asia, China, Russia

Habitats: Sandy soil, mountain slopes, lowland grassy areas, river valleys

Properties, Actions, Indications, etc.              Category: Clear Heat Dry Dampness 
English: Sophora Root    Pinyin:  Ku Shen      Pharmaceutical: Radix Sophorae Flavescentis    
Organs: Bladder • Heart • Liver • Large Intestine • Stomach        Temperature: Cold
Taste: Bitter        Toxicity:
Patterns: Damp heat • Wind • Parasites • Itching 
Actions:  Promote urination • Kill parasites • Clear heat • Dry dampness • Alleviate itching • Dispel wind
Indications: Lower burner damp heat • Itching • Jaundice • Skin lesions • Bleeding hemorrhoids •  Odorous vaginal discharge • 
Contraindications: Spleen deficiency cold • Stomach deficiency cold • Fever-less kidney deficiency
Typical Dosage: 3g - 10g; Max 30 g          Guidelines
Parts Used: Root  
Other:
Combine With Purpose
+ Mu Xiang + Gan Cao Diarrhea, damp heat dysentery3,18
+ Huang Bai + She Chuang Zi + Ming Fan Itching - skin lesions and abscesses  (topical)3,18
+ Chan Tui + Jing Jie Itching- skin only (topical)3,18
She Chuang Zi Itching - genitals (topical)18
Use alone as wash Genital sores18
+ Da Feng Zi + Cang Er Zi Leprosy3,18
+ Bai Xian Pi + Chi Shao + Hong Hua + Sang Zhi + Fang Feng + Lian Qiao + Chuan Shan Jia + Zao Jiao Ci + Chan Tui + She Tui   Uticaria (hives)3,18
Use alone or + Che Qian Zi + Pu Gong Ying Dysuria/painful urination,  irritative bladder symptoms3,18
+ Zhi Zi + Huang Bai + Long Dan Cao Jaundice18
+ Ku Lian Pi Hemorrhoid pain3,18
+ She Chuang Zi + Dan Shen Eczema3
+ Huai Hua + Di Yu Bleeding hemorrhoids3
+ Dang Gui + Zhe Bei Mu Pregnancy urinary difficulty3

Alert
Be cautions with all medicine.
  • Ku Shen contains furanocoumarins, which causes a grapefruit effect on certain medications.  Furanocoumarins can inhibit enteric CYP3A, which impacts the activity of drug metabolizing enzymes.  This can lead to an overdose or poor absorption of some medication.  
  • Ku Shen has cytosine, which can be toxic like nicotine.  Overdose can lead to poisoning.
Potential Drug Interactions

Herbal medicine may interact negatively with pharma drugs and other herbs.  Examples below:

Herbs: Incompatible with Li Lu • Antagonizes Lou Lu, Tu Si Zi, and Bei Mu ♦ Grapefruit Effect: Dang Gui, Bai Zhi, Ban Xia, Ku Shen

Pharma Drugs:♦ Grapefruit Effect: benzodiazepines midazolam (anit-depressants) , blood pressure reducers , terfenadine (antihistamine) , triazolam (anti-depressants)

Bibliography: [5],[8],[15]

Information in this post came from many sources, including class notes, practitioners, websites, webinars, books, magazines, and editor's personal experience.  While the original source often came from historical Chinese texts,  variations may result from the numerous English translations.   Always consult a doctor prior to using these drugs.  The information here is strictly for educational purposes. 

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