Wu Zhu Yu – AiQUIN.com

Evodia, Wú Zhū Yú, 吳茱萸, Evodiae Fructus

Disclaimer For educational purposes only. Do not use as medical advice

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Health Benefits

For: Epigastric pain • Headache • Gastritis • Indigestion • Vomiting • Bulging disorder (hernia) • Oral ulcers • Abdominal pain • Chest pain

Attributes: Analgesic • Antiemetic • Antidiarrheal • Anti-inflammatory • Anticancer • Antibacterial • Antibiotic • Antiallergic • Antidementia • Astringent • Stomachic

Products (online examples)

Research (sample)

Articles:

Antiallergic: In Vitro and in Vivo Antiallergic Effect of the Fructus of Evodia rutaecarpa and Its Constituents
Anti-inflammatory: Anti-inflammatory principles from the fruits of Evodia rutaecarpa and their cellular action mechanisms.
Anti-infectious: Anti-inflammatory and anti-infectious effects of Evodia rutaecarpa (Wuzhuyu) and its major bioactive components
Ovarian cancer: Evodiamine from Evodia rutaecarpa induces apoptosis via activation of JNK and PERK in human ovarian cancer cells.
Obesity: Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist
Endotaxemia: Evodia rutaecarpa protects against circulation failure and organ dysfunction in endotoxaemic rats through modulating nitric oxide release.
Benign Prostatic Hyperplasia: Ethanol Extract of Evodia rutaecarpaAttenuates Cell Growth through Caspase-Dependent Apoptosis in Benign Prostatic Hyperplasia-1 Cells
Gastric lesions: Protective effects of Evodia rutaecarpa water extract on ethanol-induced rat gastric lesions

Constituents:
Evodene • Rutaecarpa • Limonene • Evodiamine • Myrcene • Evodinone • Evocarpine • Phytosteroles • Evogine • Dihydroevocarpine • Limonin • Evodol • Limonoids • obacunone • Rutaevine acetate • Beta Trans-ocimene • Beta Elemene • Evodin • Trans Caryophyllene • Lauric acid • Linolenic acid • Palmitic acid • Stearic acid • Goshuyuic acid

Photos (Click to enlarge)

Fun Facts

Other Names: Evodia officinalis • Evodia Lepta • Evodiamine • Gosyuyu • Evodia Rutaecarpa • Wu Yu • Sheng Wu Zhu Yu • Dan Wu Zhu Yu • Chao Wu Zhu Yu
Plant Family: Rutaceae

There are many supplements marketing Rutaecarpine (a chemical from unripe Evodia fruit) as a sleep remedy by removing caffeine from one's system. Use these products with caution since long term use of Evodia fruit can cause liver damage and overdose can cause cardiac issues. See "caution" section.

Species
None noted

Growth

Euodia ruticarpa is NOT in the USDA Plant Database.

USA: Euodia ruticarpa is not available in the wild. USDA Zones: 4-8a

Native: China, Norther India (Sikkim)

Habitats: Mountains, valleys, 2000m<elevation<3000m

Properties, Actions, Indications, etc. Category: Warm Interior Expel Cold

English: Evodia Pinyin: Wu Zhu Yu Pharmaceutical: Evodiae Fructus

Organs: Liver • Spleen • Stomach Temperature: Hot

Taste: Bitter • Pungent • Slightly toxic Toxicity: Slightly toxic; overdose can cause hallucinations and visual impairment, abdominal pain, and diarrhea

Patterns: Rebellious Qi • Cold dampness • Middle burner cold • Congealing cold • Cold liver

Actions: Heats middle burner • Disperse cold • Dry dampness • Warm liver • Relieve nausea • Stop vomiting • Push heat downward • Reduce chest pain • Reduce abdominal pain

Indications: Cold bulging disorder in the liver channel • Congealing cold • Rebellious Qi • Cold dampness • Vomiting • Diarrhea

Contraindications: Long term use may cause liver damage • Pregnancy • Vomiting from stomach fire • Abdominal pain from blood deficiency with fire • Yin deficiency and heat

Typical Dosage: 1.5g to 4.5g Guidelines

Parts Used: Fruit

Other: Primarily a Liver warming herb and is very drying.

Combine With	Purpose
Sheng Jiang + Ren Shen	Lesser yin stage cold: Epigastric pain, headaches, migraines, and vomiting [3],[18],[21]
Ai Ye + Xiang Fu	Cold womb menstrual cramps [3],[21]
Ai Ye + Gui Zhi + Dang Gui + Xiang Fu + Wu Ling Zhi + Yan Hu Suo	Cold womb menstrual cramps [3],[18]
Ai Ye + Chuan Xiong + Xiang Fu + Xiao Hui Xiang	Cold womb menstrual cramps with scant, dark blood [17]
Gan Jiang + Zhi Ban Xia	Stomach cold: vomiting, acid regurgitation, and abdominal discomfort [3],[21]
Gan Jiang + Gui zhi	Cold dampness: Epigastric and adominal pain [3],[18]
Wu Wei Zi + Bu Gu Zhi + Rou Dou Kou	Spleen and Kidney yang deficiency and cold: chronic/morning diarrhea [3],[17][18],[21].
Bai Shao + Huang Lian	Liver/spleen disharmony: abdominal pain, diarrhea, acid regurgitation [3],[21]. Spleen cold/dampness [18]
Mu Gua + Bing Lang	Cold damp leg Qi pain [3],[18],[21]. (– Bing Lang) [17]
Vinegar	Sores: Mix with Wu Zhu Yu powder and apply to soles of feet for mouth sores and tongue sores. [18],[21]
Huang Lian	Liver/stomach disharmony: epigastric pain, acid regurgitation, vomiting[3],[18],[21]
Huang Lian + Gua Lou + Zhu Ru	Liver/Stomach disharmony, acid regurgitation, vomiting, dry mouth, hypochondriac pain.[17]
Wu Yao + Xiao Hui Xiang	Cold bulging disorders (hernia)[3],[21]
Wu Yao + Qing Pi + Rou Gui + Li Zhi He	Cold bulging disorders (hernia)[17]
Gui Zhi + Dang Gui + Mu Dan Pi	Blood stasis and cold in the Conception and Penetrating vessels: infertility and irregular periods [3],[21]
Wu Yao + Qing Pi + Ju He + Xiao Hui Xiang + Li Zhi He	Hernial pain [3],[18]
Xiao Hui Xiang + Wu Yao	Abdominal pain or hernia pain [18]
Chai Hu + Yu Jin + Chuan Lian Zi + Dai Zhe Shi	Liver/Stomach disharmoney: vomiting, acid regurgitation, abdominal distention and belching [17]
Sheng Jiang + Ban Xia + Gao Liang Jiang + Huo Xiang + Sha Ren	Stomach deficiency and cold: vomiting, nausea, abdominal pain and acid regurgitation [3],[18]. (– Huo Xiang)[17].
Water	Eczema: Mix with Wu Zhu Yu powder and apply to eczema. [18],[21]
Hai Piao Xiao + Liu Huang	Eczema: apply topically to eczema [17]

Formulas with Wu Zhu Yu

Ji Ming San • Si Shen Wan • Xiang Lian Wan • Wen Jing Tang • Wu Zhu Yu Tang • Zuo Jin Wan

Variations for Wu Zhu Yu

Bland Evodia Fruit, Wu Zhu Yu, Dan Wu Zhu Yu: Reduced toxicity through soaking in water or with licorice roots. It is then dried.

Raw Evodia Fruit, Sheng Wu Zhu Yu: Only used topically because of its toxicity.

Processed Evodia Fruit, Zhi Wu Zhu Yu, Zhi Wu Yu: Soaked in licorice water and then baked in low heat. Best for stopping pain.

Stir Fried Evodia Fruit, Chao Wu Zhu Yu: Soaked in water, dried, and then stir fried until color darkens.

Evodia fruit is also soaked with various herbs to provide variation in benefits, including Huang Lian, Vinegar, Saltwater, and Ginger. ^[21]

Alert

Be cautions with all medicine.

Hepatotoxicity: Long term use or overdose can cause liver damage. This herb is slightly toxic and toxicity can accumulate over time. [ref1], ^[ref2]
Using Evodia Rutaecarpa as a decaffeinating agent can impact the metabolism of drugs (antidepressants, blood thinners, etc) since the rutaecarpine in Evodia fruit inhibits the liver enzyme CYP1A2 and CYPE1. ^[ref]
Cardiotoxicity: Evodia fruit can reduce circulation and pericardial malformation in cardiovascular function. Use with caution if taking blood thinner or are at risk of blood clots. ^[ref]

Potential Drug Interactions

Herbal medicine may interact negatively with pharma drugs and other herbs. Examples below:

Herbs:

Pharma Drugs:

[3],[5],[8],[17],[18],[21]

Information in this post came from many sources, including class notes, practitioners, websites, webinars, books, magazines, and editor's personal experience. While the original source often came from historical Chinese texts, variations may result from the numerous English translations. Always consult a doctor prior to using these drugs. The information here is strictly for educational purposes.

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