Evodia, Wu Zhu Yu, 吳茱萸, Euodia ruticarpa

Disclaimer    For educational purposes only.  Do not use as medical advice

AboutPlantsChinese MedicineCaution
Health Benefits
For: Epigastric pain • Headache • Gastritis • Indigestion • Vomiting • Bulging disorder (hernia) • Oral ulcers • Abdominal pain • Chest pain
Attributes: Analgesic • Antiemetic • Antidiarrheal • Anti-inflammatory • Anticancer • Antibacterial • Antibiotic • Antiallergic • Antidementia • Astringent • Stomachic
Products (online examples)

Dried Herb

Granules

Dried Herb

Skin Tonic

Extract

Dried Herb

Facial Tonic

Granules

Research (sample)
Articles:
Constituents: 
Evodene • Rutaecarpa • Limonene • Evodiamine • Myrcene • Evodinone • Evocarpine • Phytosteroles • Evogine • Dihydroevocarpine • Limonin • Evodol • Limonoids • obacunone • Rutaevine acetate • Beta Trans-ocimene • Beta Elemene • Evodin • Trans Caryophyllene • Lauric acid • Linolenic acid • Palmitic acid • Stearic acid • Goshuyuic acid

Photos (Click to enlarge)
Fun Facts
Other Names: Evodia officinalis • Evodia Lepta • Evodiamine • Gosyuyu • Evodia Rutaecarpa • Wu Yu • Sheng Wu Zhu Yu • Dan Wu Zhu Yu • Chao Wu Zhu Yu
Plant Family: Rutaceae
There are many supplements marketing Rutaecarpine (a chemical from unripe Evodia fruit) as a sleep remedy by removing caffeine from one's system.  Use these products with caution since long term use of Evodia fruit can cause liver damage and overdose can cause cardiac issues.  See "caution" section.
Species
None noted
Growth
Euodia ruticarpa is NOT in the USDA Plant Database.  

USA: Euodia ruticarpa is not available in the wild.    USDA Zones: 4-8a 

Native: China, Norther India (Sikkim)

Habitats: Mountains, valleys, 2000m<elevation<3000m 

Properties, Actions, Indications, etc.              Category: Warm Interior Expel Cold 
English: Evodia    Pinyin:  Wu Zhu Yu      Pharmaceutical: Evodiae Fructus   
Organs: Liver • Spleen • Stomach        Temperature: Hot     
Taste: Bitter • Pungent      Toxicity: Slightly toxic; overdose can cause hallucinations and visual impairment, abdominal pain, and diarrhea  
Patterns: Rebellious Qi • Cold dampness • Middle burner cold • Congealing cold • Cold liver 
Actions:  Heats middle burner • Disperse cold • Dry dampness • Warm liver • Relieve nausea • Stop vomiting • Push heat downward • Reduce chest pain • Reduce abdominal pain
Indications: Cold bulging disorder in the liver channel • Congealing cold • Rebellious Qi • Cold dampness • Vomiting • Diarrhea
Contraindications: Long term use may cause liver damage • Pregnancy • Vomiting from stomach fire • Abdominal pain from blood deficiency with fire • Yin deficiency and heat
Typical Dosage: 1.5g to 4.5g          Guidelines
Parts Used: Fruit  
Other: Primarily a Liver warming herb and is very drying.
Combine With Purpose
Sheng Jiang + Ren Shen Lesser yin stage cold: Epigastric pain, headaches, migraines, and vomiting [3],[18],[21]
Ai Ye + Xiang Fu Cold womb menstrual cramps [3],[21]
Ai Ye + Gui Zhi + Dang Gui + Xiang Fu + Wu Ling Zhi + Yan Hu Suo Cold womb menstrual cramps [3],[18]
Ai Ye + Chuan Xiong + Xiang Fu + Xiao Hui Xiang Cold womb menstrual cramps with scant, dark blood [17]
Gan Jiang + Zhi Ban Xia Stomach cold: vomiting, acid regurgitation, and abdominal discomfort [3],[21]
Gan Jiang + Gui zhi Cold dampness: Epigastric and adominal pain [3],[18]
Wu Wei Zi + Bu Gu Zhi + Rou Dou Kou Spleen and Kidney yang deficiency and cold: chronic/morning diarrhea [3],[17][18],[21]. 
Bai Shao + Huang Lian Liver/spleen disharmony: abdominal pain, diarrhea, acid regurgitation [3],[21].  Spleen cold/dampness [18]
Mu Gua + Bing Lang Cold damp leg Qi pain [3],[18],[21]. (– Bing Lang) [17]
Vinegar Sores: Mix with Wu Zhu Yu powder and apply to soles of feet for mouth sores and tongue sores. [18],[21]
Huang Lian Liver/stomach disharmony: epigastric pain, acid regurgitation, vomiting[3],[18],[21]
Huang Lian + Gua Lou + Zhu Ru Liver/Stomach disharmony, acid regurgitation, vomiting, dry mouth, hypochondriac pain.[17]
Wu Yao + Xiao Hui Xiang Cold bulging disorders (hernia)[3],[21]
Wu Yao + Qing Pi + Rou Gui + Li Zhi He Cold bulging disorders (hernia)[17]
Gui Zhi + Dang Gui + Mu Dan Pi Blood stasis and cold in the Conception and Penetrating vessels: infertility and irregular periods [3],[21]
Wu Yao + Qing Pi + Ju He + Xiao Hui Xiang + Li Zhi He Hernial pain [3],[18]
Xiao Hui Xiang + Wu Yao Abdominal pain or hernia pain [18]
Chai Hu + Yu Jin + Chuan Lian Zi + Dai Zhe Shi Liver/Stomach disharmoney: vomiting, acid regurgitation, abdominal distention and belching [17]
Sheng Jiang + Ban Xia + Gao Liang Jiang + Huo Xiang + Sha Ren Stomach deficiency and cold: vomiting, nausea, abdominal pain and acid regurgitation [3],[18].  (– Huo Xiang)[17].
Water Eczema: Mix with Wu Zhu Yu powder and apply to eczema. [18],[21]
Hai Piao Xiao + Liu Huang Eczema: apply topically to eczema [17]
Formulas with Wu Zhu Yu
Ji Ming San • Si Shen Wan • Xiang Lian Wan • Wen Jing Tang • Wu Zhu Yu Tang Zuo Jin Wan
Variations for Wu Zhu Yu

Bland Evodia Fruit, Wu Zhu Yu, Dan Wu Zhu Yu: Reduced toxicity through soaking in water or with licorice roots.  It is then dried.  

Raw Evodia Fruit, Sheng Wu Zhu Yu: Only used topically because of its toxicity.  

Processed Evodia Fruit, Zhi Wu Zhu Yu, Zhi Wu Yu: Soaked in licorice water and then baked in low heat.  Best for stopping pain.

Stir Fried Evodia Fruit, Chao Wu Zhu Yu: Soaked in water, dried, and then stir fried until color darkens.

Evodia fruit is also soaked with various herbs to provide variation in benefits, including Huang Lian, Vinegar, Saltwater, and Ginger. [21]

Alert
Be cautions with all medicine.
  • Hepatotoxicity: Long term use or overdose can cause liver damage.  This herb is slightly toxic and toxicity can accumulate over time.  [ref1], [ref2]
  • Using Evodia Rutaecarpa as a decaffeinating agent can impact the metabolism of drugs (antidepressants, blood thinners, etc) since the rutaecarpine in Evodia fruit inhibits the liver enzyme CYP1A2 and CYPE1.  [ref]
  • Cardiotoxicity: Evodia fruit can reduce circulation and pericardial malformation in cardiovascular function.  Use with caution if taking blood thinner or are at risk of blood clots. [ref]
Potential Drug Interactions

Herbal medicine may interact negatively with pharma drugs and other herbs.  Examples below:

Herbs:

Pharma Drugs:

[3],[5],[8],[17],[18],[21]

Information in this post came from many sources, including class notes, practitioners, websites, webinars, books, magazines, and editor's personal experience.  While the original source often came from historical Chinese texts,  variations may result from the numerous English translations.   Always consult a doctor prior to using these drugs.  The information here is strictly for educational purposes. 

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